TABLE 4.
KLF5 targeted compounds
| Compounds | Functional mechanism | References |
|---|---|---|
| CID51003603(ML264) | Inhibit the expression of EGR1 and KLF5 | 128, 190 |
| CID5951923, CID46931043, CID46931037 | Inhibit the expression of EGR1 and KLF5 | 189 |
| Metformin | Promote KLF5 phosphorylation and degradation | 6 |
| Mifepristone | Induce miR‐153 to inhibit KLF5 protein translation | 75 |
| Mithramycin A | Inhibit the binding of Sp1 to the KLF5 promoter | 160 |
| Curcumin | Inhibit YAP/TAZ | 68 |
| Crocin | Induce miR‐320 | 83 |
| JQ‐1 and compound 870 | BRD4 inhibitors | 73 |
| THZ1 | CDK7 inhibitor | 73 |
| Sodium butyrate | Histone deacetylase inhibitor | 173 |