FIGURE 5.

Treatment with OR‐S1 leads to inhibition of Retinoblastoma (RB) phosphorylation in patient‐derived xenograft (MCL) cells. A, Western blotting for levels of RB phosphorylation (at S780 and S807/811) and cyclin D1 expression. Cells were treated with vehicle control, GSK126, or OR‐S1 at three different concentrations (300, 1000, and 5000 nmol/L) for 5 d and then lysed for analysis. β‐actin was used as a loading control. pRB, phosphorylated RB. B, Model showing the molecular mechanisms underlying the efficacy of OR‐S1 as a growth inhibitor of MCL cells. Findings in this study are highlighted in red font, a bar, and an arrow