FIGURE 3.

Malate dehydrogenase 2 expression is upregulated in lung cancer tissues. A, MDH2 RNA expression levels in paired normal lung tissue and cancer tissue (n = 19) were analyzed using qPCR. MDH2 expression is higher in lung cancer tissues compared with normal lung tissues. P =.0067 using Wilcoxon test. B, MDH2 protein levels in paired normal lung tissue and lung cancer tissue (n = 8) determined in triplicate using western blot analysis. The column graph indicates semi‐quantitative analysis. P =.0078 using Wilcoxon test. C, Representative images of immunohistochemical staining of MDH2 in LUAD, LUSC and normal lung tissue. Magnification ×10 (top) and ×20 (bottom). LUAD, lung adenocarcinoma; LUSC, lung squamous carcinoma