TABLE 3.
COX proportional hazards model for PDX engraftment
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| Coefficients | 95% CI | P value | Coefficients | 95% CI | P value | |
| Sex (Female vs male) | 0.06 | −0.23‐0.35 | .699 | |||
| Age (75< vs ≥75) | −0.22 | −0.63‐0.19 | .299 | −0.29 | −0.89‐0.31 | .340 |
| Specimen (Surgical vs biopsy) | 0.07 | −0.24‐0.38 | .664 | −0.17 | −0.71‐0.36 | .528 |
| Time to transplantation (Short vs long) | −0.43 | −0.80‐−0.46 | .028 | −0.21 | −0.76‐0.35 | .463 |
| Stage (I, II vs III, IV, Rec) | 0.54 | 0.19‐0.88 | .002 | 0.54 | 0.01‐1.07 | .046 |
| PS (0 vs 1‐4) | 0.09 | −0.24‐0.42 | .587 | |||
| Smoking history (No vs yes) | 0.05 | −0.24‐0.34 | .725 | 0.09 | −0.35‐0.52 | .696 |
| Cancer type (Major cancer vs rare cancer) | −0.14 | −0.49‐0.20 | .414 | |||
| Prior‐chemotherapy (naïve vs resistant) | 0.39 | 0.08‐0.70 | .014 | 0.37 | −0.17‐0.91 | .181 |
| OS (Long vs short) | 4.19 | 3.63‐4.75 | .001 | 4.13 | 3.56‐4.70 | .001 |
Abbreviations: CI, confidence interval; OS, overall survival; PDX, patient‐derived xenograft; PS, performance status.
Bold italics indicate P value < .05.