Table 1.
Ki Values for 25 Drug Metabolites.
| Drug Metabolite | Molecular Weight (g/mol)a | Ki (μM) |
Potency (hOAT3/hOAT1) | |
|---|---|---|---|---|
| OAT1 | OAT3 | |||
| Abiraterone N-oxide sulfate (DBMET00951) | 445.572 | >100 | 1.36 | NA |
| (S)-naproxen acyl-β-D-glucuronide (DBMET00160) | 400.4648 | >200 | 5.43 | NA |
| 4-hydroxy-trazodone (DBMET00405) | 387.863 | >200 | 16.9 | NA |
| Imatinib (piperidine)-4-oxide (DBMET00027) | 510.622 | >200 | 64.2 | NA |
| Sulindac sulfone (DBMET01003) | 372.41 | 23.0 | 0.60 | 38.4 |
| Celecoxib carboxylic acid (DBMET00810) | 411.355 | 262 | 8.43 | 31.1 |
| N-desmethyl rosiglitazone (DBMET00295) | 343.4 | 33.3 | 1.15 | 28.9 |
| 5-Carboxy-meloxicam (DBMET00754) | 381.384 | 19.6 | 0.70 | 27.9 |
| 5-OH-rosiglitazone sulfate (DBMET01112) | 453.489 | 33.7 | 1.31 | 25.8 |
| Abiraterone sulfate (DBMET00788) | 429.572 | 38.2 | 1.83 | 20.9 |
| Hydroxy pioglitazone (DBMET01306) | 372.438 | 27.6 | 1.37 | 20.2 |
| Keto pioglitazone (DBMET01307) | 370.422 | 12.5 | 0.73 | 17.2 |
| 3-cis-hydroxycyclohexyl glyburide (DBMET01806) | 510.003 | 10.1 | 0.81 | 12.5 |
| (S)-7-hydroxy warfarin (DBMET01042) | 324.3273 | 14.5 | 1.93 | 7.48 |
| Losartan carboxylic acid (DBMET00303) | 436.9 | 0.69 | 0.10 | 6.66 |
| Probenecid acyl β-D-glucuronide | 461.5 | 130 | 19.9 | 6.56 |
| O-desmethyl indomethacin (DBMET00156) | 343.8 | 1.62 | 0.27 | 6.01 |
| Sulindac sulfide (DBMET01002) | 340.411 | 3.68 | 0.66 | 5.56 |
| (S)-ketoprofen β-D-glucuronide (DBMET00589) | 430.4047 | 40.2 | 8.07 | 4.98 |
| Tolmetin β-D-glucuronide (DBMET00652) | 433.4086 | 7.17 | 2.92 | 2.46 |
| (S)-O-desmethyl naproxen (DBMET00159) | 216.2326 | 4.70 | 3.44 | 1.37 |
| 4-Hydroxy flurbiprofen (DBMET00151) | 260.2603 | 1.60 | 1.39 | 1.15 |
| 6-Hydroxy chlorzoxazone (DBMET00327) | 185.565 | 3.60 | 3.21 | 1.12 |
| 4-Hydroxy diclofenac (DBMET00144) | 312.148 | 0.48 | 2.03 | 0.24 |
| 5-Hydroxy Rosiglitazone β-D-Glucuronide (DBMET00981) | 549.55 | >200 | >200 | NA |
| Estrone sulfate | 350.4 | 170 | 1.00 | 170 |
NA: Not available.
a
Data from Drugbank or PubChem.