Table 2.
Ki Values for 19 Parent Drugs.
| Drug | Molecular Weight (g/mol)a | Ki (μM) |
Potency (hOAT3/hOAT1) | |
|---|---|---|---|---|
| OAT1 | OAT3 | |||
| Indomethacin | 357.788 | 4.35 | 0.11 | 39.5 |
| Sulindac | 356.411 | 56.8 | 1.65 | 34.4 |
| Losartan | 422.911 | 11.4 | 0.36 | 31.7 |
| Glyburide | 494.004 | 5.7 | 0.21 | 27.1 |
| Meloxicam | 351.401 | 6.88 | 0.54 | 12.7 |
| Rosiglitazone | 357.427 | 4.2 | 0.59 | 7.12 |
| Trazodone | 371.864 | 19.9 | 2.94 | 6.77 |
| Probenecid | 285.359 | 7.74 | 1.25 | 6.19 |
| Pioglitazone | 356.439 | 6.3 | 1.02 | 6.18 |
| Chlorzoxazone | 169.565 | 52.3 | 10.2 | 5.13 |
| Warfarin | 308.3279 | 15.8 | 3.11 | 5.08 |
| Tolmetin | 257.2845 | 3.01 | 0.81 | 3.72 |
| Diclofenac | 296.149 | 1.67 | 0.62 | 2.69 |
| Imatinib | 493.6027 | 29.2 | 14.5 | 2.01 |
| Ketoprofen | 254.2806 | 1.73 | 1.61 | 1.07 |
| Flurbiprofen | 244.2609 | 1.91 | 1.8 | 1.06 |
| Naproxen | 230.2592 | 3.23 | 4.75 | 0.68 |
| Celecoxib | 381.372 | >200 | >200 | NA |
| Abiraterone | 349.509 | >20 | >20 | NA |
NA: Not available.
a
Data from Drugbank or PubChem.