Table 6. Results of Studies Combining Chemoradiotherapy with Immunotherapy in Stage III NSCLC.
n | Intervention | DFS | OS (%) | Toxicity>Grade 3 (%) | |
---|---|---|---|---|---|
PACIFIC [6,117] | 714 | CRT (54–66 Gy)→Durvalumab. | Median, 18.8 months | 1 year: 83.1 2 year: 66.3 | 30.5 |
LUN 14-179 [119] | 92 | CRT (59.4–66 Gy)→Pembrolizumab. | Median, 15.4 months | 1 year: 80.5 2 year: 68.7 | 6.5 |
ETOP NICOLAS [121,125] | 80 | CRT (66 Gy)+Nivolumab→Nivolumab 1 year | 1 year: 54% | 1 year: 79 | 10.9 |
DETERRED [120] | 40 | Part 1: CRT (60–66 Gy)→CT+Atezolizumab×2 cycles→Atezolizumab 1 year Part 2: CRT (60–66 Gy)+Atezolizumab→CT+Atezolizumab×2 cycles→Atezolizumab 1 year | 1 year: 57% | 1 year: 79 | 27.5 |
DFS: Disease-free survival, OS: Overall survival, CRT: Chemoradiotherapy, CT: Chemotherapy