Figure 3.
Ketotifen fumarate inhibition of formalin test responding is MC-dependent. Graphs display the early phase (A; 0–10 min post‐injection) and late phase (B; 10–60 min post‐injection) nocifensive behavior of wild-type (C57BL/6) and MC-deficient (C57BL/6-KitW-sh/W-sh) mice after 5% formalin injection into the plantar hind paw; bars (n = 12–15 mice/genotype/drug) represent mean ± SEM percentage of samples featuring licking behavior (% positive samples). *P < 0.01, ***P < 0.001 as indicated; all other comparisons not significant. MC, mast cell.