Figure 4.
Ketotifen fumarate inhibition of CFA-induced mechanical allodynia is MC-dependent. Mechanical allodynia produced by CFA is reversed by treatment with 4.5 mg/kg KF but not saline (n = 10 mice/drug) in C57BL/6 (A; n = 12–14 mice/drug) but not in MC-deficient KitW-sh/W-sh mice (B; n = 7–8 mice/drug). Bars represent mean ± SEM ipsilateral hind paw withdrawal threshold at baseline (BL), 3 days after CFA (pre-injection; Pre), and 30 minutes post-injection of KF (Post). **P < 0.01, ***P < 0.001 as indicated; CFA, complete Freund's adjuvant; MC, mast cell; n.s., not significant; KF, ketotifen fumarate.