Table 1.

List of FDA approved drugs for the treatment of GIST and their corresponding targeted molecule

Target	Drugs	Indication
KIT, PDGFR, ABL	Imatinib	First-line
PDGFR, VEGFR1/2/3, KIT	Sunitinb	Second-line
KIT, PDGFR, RAF, VEGFR1/2/3	Regorafenib	Third-line
PDGFRA	Avapritinib	PDGFRA exon 18 mutation including D842V mutation