Table 12.
Renal enzymatic antioxidant activities of Cnidoscolus aconitifolius and ascorbate treatments in DMN-induced toxicity.
| Groups | GST (nmol/min/mgprotein) | GPx (μg/mL/mgprotein) | SOD (Unit/mgprotein) | CAT (μmol/min/mgprotein) |
|---|---|---|---|---|
| Control | 17.28 ± 2.75abcd | 115.77 ± 11.36bcde | 0.57 ± 0.11bc | 343.84 ± 36.53abc |
| 200 CA | 11.37 ± 1.59a | 86.18 ± 4.66ab | 0.49 ± 0.06ab | 282.77 ± 16.36a |
| 400 CA | 15.79 ± 3.37abc | 88.79 ± 2.48ab | 0.59 ± 0.07bc | 298.86 ± 7.77ab |
| 400 VitC | 13.64 ± 0.96ab | 88.83 ± 2.32ab | 0.65 ± 0.02bcd | 297.71 ± 7.87ab |
| DMN | 29.93 ± 3.38e | 141.08 ± 3.68e | 0.84 ± 0.02e | 443.58 ± 9.67d |
| DMN + 200 CA | 21.64 ± 2.06bcd | 91.33 ± 3.23abc | 0.64 ± 0.02bcd | 309.95 ± 20.02ab |
| 200 CA + DMN | 21.51 ± 2.81bcd | 108.12 ± 10.86abcd | 0.66 ± 0.05bcd | 358.97 ± 34.67abcd |
| DMN + 400 CA | 22.56 ± 5.96cde | 127.64 ± 14.99de | 0.79 ± 0.05de | 427.58 ± 50.79cd |
| 400 CA + DMN | 19.05 ± 1.66abcd | 101.50 ± 6.48abcd | 0.74 ± 0.05cde | 341.93 ± 19.79abc |
| DMN + 400ASC | 11.91 ± 3.05a | 96.53 ± 23.15abc | 0.65 ± 0.13bcd | 322.09 ± 75.80ab |
| 400ASC + DMN | 13.46 ± 0.37ab | 81.50 ± 2.94a | 0.57 ± 0.03bc | 272.84 ± 9.10a |
Values are expressed as mean ± SEM; n = 5. Values with different superscript along the same column are statistically significant (p values < 0.05). DMN = dimethyl nitrosamine; CA =Cnidoscolus aconitifolius; ASC = Ascorbate.