Table 1.
CN (n = 127) | MCI (n = 106) | ADc (n = 84) | Non-AD (n = 34) | p value | |
---|---|---|---|---|---|
Age | 73.9 ± 6.8 | 71.7 ± 9.0 | 66.1 ± 9.2 | 65.3 ± 9.7 | p ≤ .001† |
Sex (M, %) | 45 (35%) | 47 (44%) | 44 (52%) | 20 (59%) | p = .03 |
Education | 14.9 ± 3.8 | 15.8 ± 3.0 | 15.5 ± 3.5 | 17.4 ± 4.2 | p = .004†† |
MMSE | 29.2 ± 1.0 | 27.0 ± 2.7 | 20.9 ± 4.8 | 25.2 ± 6.3 | p <.001††† |
Amyloid status (Aβ+, %) | 48 (38%) | 61 (58%) | 81 (96%) | 6 (18%) | p < .001 |
Provenance | UCSF ADRC 0 | UCSF ADRC 15 | UCSF ADRC 50 | UCSF ADRC 33 | |
ADNI 80 | ADNI 83 | ADNI 16 | ADNI 0 | ||
BioFINDER 47 | BioFINDER 8 | BioFINDER 18 | BioFINDER 1 |
CN cognitively normal, MCI mild cognitive impairment, ADc Alzheimer’s disease dementia, non-ADc non-AD disorders (including patients with clinical diagnoses of behavioral variant frontotemporal dementia, non-fluent variant primary progressive aphasia, progressive supranuclear palsy, corticobasal syndrome, dementia with Lewy bodies, and one subject with chronic traumatic encephalopathy)
Significant for all pairwise comparisons except CN vs MCI (p = .26) and AD vs non-AD (p = 1.00)
Pairwise comparisons significant only between CN and non-AD (p = .002)
Significant for all pairwise comparisons except MCI vs non-AD (p = 1.00)