Table 1.
Patient Characteristics
| Total N (%) | Cohort 1: Relapsed/Refractory N (%) | Cohort 2: Newly Diagnosed N (%) | |
|---|---|---|---|
| N | 153 | 101 | 52 |
| Sex | |||
| Female | 73 (48) | 46 (46) | 27 (51) |
| Male | 80 (52) | 55 (54) | 25 (48) |
| Age (yrs.) at sample, median (range) | 11 (<1, 26) | 11 (1, 25) | 7 (<1, 26) |
| < 1 yrs. | 6 (11) | 0 (0) | 6 (11) |
| 1 – 9 yrs. | 64 (42) | 41 (41) | 23 (44) |
| 10 – 17 yrs. | 54 (35) | 38 (38) | 16 (31) |
| ≥ 18 yrs. | 29 (19) | 22 (22) | 7 (13) |
| Disease | |||
| AML | 67 (44) | 34 (34) | 33 (63) |
| MDS | 1 (<1) | 0 (0) | 1 (2) |
| JMML | 3 (2) | 1 (1) | 2 (4) |
| ALL | 59 (39) | 56 (56) | 3 (6) |
| B-cell | 49 | 48 | 1 |
| T-cell | 10 | 8 | 2 |
| Infant KMT2A-rearranged ALL | 3 (2) | 1 (1) | 2 (4) |
| Leukemia of ambiguous lineage | 9 (6) | 4 (4) | 5 (9) |
| Other rare leukemia | 4 (3) | 2 (2) | 2 (4) |
| Therapy-related leukemia | 7 (5) | 3 (3) | 4 (8) |