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. Author manuscript; available in PMC: 2022 Jun 15.
Published in final edited form as: Biol Psychiatry. 2021 Jan 21;89(12):1162–1175. doi: 10.1016/j.biopsych.2021.01.007

Figure 6. CRF-containing neuron stimulation in CeA biases and amplifies sucrose motivation.

Figure 6.

CeA ChR2 excitation of CRF-containing neurons caused near-exclusive preference for Laser+Sucrose over Sucrose-alone rewards in two-choice test (n=4 female, n=5 male), A) reaching a 10:1 ratio by day 8. B) CeA eYFP controls chose equally between sucrose options (n=7) and differed from CeA ChR2 rats. C) CeA NpHR inhibition of CRF-containing neurons caused Laser+Sucrose avoidance and Sucrose-alone preference (n=2 female, n=5 male). D) In progressive ratio test, CeA CRF-containing neuron excitation enhanced incentive motivation for sucrose breakpoint (n=3 female, n=4 male). Laser did not affect CeA eYFP control breakpoint (n=5), which differed from ChR2 rats. CeA NpHR inhibition of CRF-containing neurons reduced Laser+Sucrose breakpoint (n=2 female, n=5 male). Means and SEM reported. *p<0.05,**p<0.01,***p<0.001