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. Author manuscript; available in PMC: 2022 Jun 15.
Published in final edited form as: Biol Psychiatry. 2021 Jan 21;89(12):1162–1175. doi: 10.1016/j.biopsych.2021.01.007

Figure 9. Place-based self-stimulation and place-based aversion following CRF-containing neuron stimulation.

Figure 9.

A) NAc supported ChR2 place-based laser self-stimulation of CRF-containing neurons. NAc ChR2 rats (n=2 female, n=6 male) spent more time in Laser-delivering chamber than in No-laser chamber, more time in Laser-delivering chamber than NAc eYFP controls (n=5), and more than they previously spent in same chamber during no-laser baseline preference tests. B) CeA also supported place-based self-stimulation of CRF-containing neurons. CeA ChR2 rats (n=5 female, n=3 male) spent more time in Laser-delivering chamber than in no-laser chamber, more time in Laser-delivering chamber than CeA eYFP controls (n=5), and more than they previously spent in identical chamber during no-laser baseline tests. C) Conversely, BNST produced avoidance the Laser-delivering chamber. BNST ChR2 rats (n=5 female, n=5 male) spent less time in Laser-delivering chamber than eYFP controls (n=5), and less time than they spent in the same chamber during no-laser baseline tests. Also see Fig. S5 and Fig. S6E. Means and SEM reported. *p<0.05