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STIM1 acts as rheostat balancing between ATF4 and NFAT-dependent transcriptional programs. (A) Scheme depicting the amplification of RRM1 and STIM1 upon gemcitabine resistance. While the upregulation of RRM1 drives gemcitabine resistance, increased STIM1 levels elicit a calcium signaling shift, leading to a dampened ER stress response and an aberrant NFAT activation.
