Table 2.

Regression coefficients and 95% confidence intervals (CIs) for associations between pre-pregnancy BMI and cytokine/chemokine concentrations.

	*Plasma Concentration	All N = 348			Whites N = 141			African Americans N = 182
Cytokine	Median (IQR)	β ** (95% CI)	T- β	p value	β ** (95% CI)	T- β	p value	β ** (95% CI)	T- β	p value
TNFα	4.7 (3.5–6.2)	0.01 (0.00,0.01)	0.57	0.03	0.00 (−0.01,0.01)	0.50	0.29	0.01 (−0.00,0.01)	0.58	0.07
IL8	4.0 (2.9–5.9)	−0.00 (−0.01,0.01)	−0.06	0.85	0.01 (−0.00,0.02)	0.68	0.16	−0.00 (−0.01,0.00)	−0.35	0.41
IL1β	4.4 (2.6–6.8)	−0.00 (−0.01,0.00)	−0.34	0.33	−0.00 (−0.01,0.01)	−0.19	0.75	−0.00 (−0.01,0.01)	−0.32	0.48
IL-17A	5.3 (2.8–10.7)	−0.00 (−0.01,0.01)	−0.03	0.95	−0.01 (−0.02,0.01)	−0.57	0.50	0.00 (−0.01,0.01)	0.13	0.85
IL4	4.1 (2.4–7.6)	−0.01 (−0.02,0.00)	−0.68	0.16	−0.01 (−0.03,0.00)	−1.03	0.18	0.00 (−0.01,0.01)	−0.18	0.79
IFN-γ	17.2 (10.5–27.3)	0.01 (−0.00,0.01)	0.89	0.06	0.0 (−0.01,0.02)	0.31	0.70	0.01 (−0.00,0.02)	1.06	0.10
IL6	2.8 (1.7–4.2)	0.01 (−0.00,0.01)	0.59	0.10	0.01 (−0.00,0.02)	0.61	0.25	0.01 (−0.00,0.02)	0.72	0.14
IL12	4.7 (2.5–7.7)	−0.00 (−0.01,0.01)	−0.28	0.55	−0.00 (−0.02,0.01)	−0.18	0.79	−0.00 (−0.01,0.01)	−0.16	0.77

Models were adjusted for maternal smoking, age, education and race (All). Whites and African Americans were run separately with non-race covariates.

^*In picograms/ml.

^**Cytokine data were zero-protected and log-transformed for regression models. T - Beta (T- β) estimates were back-transformed after regression. Example: For TNFα, each one unit increase in maternal BMI is associated with 0.57% increase in maternal plasma levels of TNFα.

^**For all, depending on cytokine, N ranged from 342–348 – N reflects Analyzed complete cases for those 3 covariates

^***For White 137–141

^****For Black 180–182