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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cancer Res. 2021 Mar 11;19(6):1005–1014. doi: 10.1158/1541-7786.MCR-20-0534

Figure 5. The repression of TTK and TFRC contributed to the ferroptosis resistance by SKP2 knockdown.

Figure 5.

(A) Validation of SKP2 knockdown by siRNA in MDA-MB-231 cells by qRT-PCR. n=3; mean ± SEM; one-way ANOVA; ****p < 0.0001.

(B-C) TTK (B) and TFRC (C) RNAs were downregulated by SKP2 knockdown in MDA-MB-231 cells by qRT-PCR. n=3; mean ± SEM; one-way ANOVA; ****p < 0.0001.

(D) Overexpression of TTK and TFRC resensitized RCC4 cells to ferroptosis protected by SKP2 knockdown. n=3; mean ± SEM; two-way ANOVA; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.