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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Apr 20;173:427–438. doi: 10.1016/j.addr.2021.04.011

Figure 5: PRRs are localized to specific subcellular compartments to screen for PAMPs and DAMPs.

Figure 5:

The endosomal and cytosolic sensors display composition, sequence, length, and structure-dependent recognition of nucleic acid ligands. The same ligand preferences determine binding to NANPs. The figure highlights key features of NANPs that meet the necessary ligand characteristics and have been experimentally confirmed to activate nucleic acid PRRs (A) with trends in relative responses in IFN productions across some representative categories of NANPs (B). Created with Biorender.com