FIGURE 4.

ATP‐binding cassette transporters A1 (ABCA1) was up‐regulated by Photobiomodulation therapy (PBMT) in Apolipoprotein E (ApoE)^−/− mice aortic tissue and peritoneal macrophages. A, Western blot (WB) analysis and quantification of ABCA1 expression in ApoE ^−/− mice aortic after treated with PBMT (n = 8). B, qPCR analysis of ABCA1 expression in ApoE ^−/− mice aortic after treated with PBMT (n = 5). C, Representative ABCA1, α‐SMA (smooth muscle cell) and CD11b (macrophage) staining in the aortic sinus after treated with PBMT. Scale bars, 200 μm. D, WB analysis and quantification of ABCA1 expression in ApoE ^−/− mice peritoneal macrophages (n = 4). E, apolipoprotein A‐I (ApoA‐I)‐mediated cholesterol efflux after treat with PBMT or DIDS in ApoE ^−/− mice peritoneal macrophages (n = 6). Data are shown as mean ± SEM, control vs PBMT, unpaired two‐tailed Student's t test. *P < .05, **P < .01, ***P < .001, ^## P < .01, ns = not significant