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. 2021 May 3;25(11):4922–4937. doi: 10.1111/jcmm.16280

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Lnc‐ISG20 knockdown in kidney tissue of DN mice can inhibit renal fibrosis. A, RT‐qPCR determination of the knockdown efficiency of AAV vector expressing sh‐lnc‐ISG20 in kidney tissues of DN mice. B, The urine albumin excretion rate in DN mice after lnc‐ISG20 knockdown. C, HE staining showing the pathological conditions of kidney tissues in DN mice after lnc‐ISG20 knockdown. D, Masson staining displaying collagen fibres in the kidney tissue of DN mice after lnc‐ISG20 knockdown. E, Western blot assay for the expression of collagen IV, fibronectin and TGF‐β1 proteins in kidney tissues of DN mice after lnc‐ISG20 knockdown. *P < .05 when compared with sh‐NC group (The results are measurement data expressed by mean ± standard deviation. The two groups were analysed by independent sample t test, and the experiment was repeated 3 times)