FIGURE 1.

Intra‐articular injection of baicalein ameliorates subchondral bone remodelling in OA. A, Representative H&E staining and safranin O staining of the articular cartilage and subchondral bone after treating osteoarthritis employing baicalein. B, The effect of baicalein on the structure of tibial subchondral bone analysed by micro‐CT. C‐F, Baicalein reduced tibial subchondral bone mineral density (BMD), bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and increased trabecular separation(Tb.Sp) compared to DMM surgery groups (**P < .01, *P < .05)