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. 2021 May 5;25(11):5220–5237. doi: 10.1111/jcmm.16530

FIGURE 4.

FIGURE 4

(A) Schematic diagram of PHx model using AD‐miR20a‐anta and AD‐control‐treated mice. (B) Adenovirus expressing miR‐20a antagomir and control were delivered into the mice liver through tail vein injection. miR‐20a‐relative expression in the liver was evaluated by Q‐PCR after treatment (n = 4 per group). (C) Q‐PCR shows the relative expression of miR‐20a in the AD‐miR20a‐antagomir and AD‐control‐treated mouse liver at different time points after PHx (n = 7 per group). (D) Kaplan‐Meier survival curves of AD‐miR20a‐antagomir‐treated mice (n = 10) and AD‐control‐treated group. (E, F) Plasma ALT and AST levels of the mice after PHx. (G) The ratio of liver weight to bodyweight was examined. (H, I) Representative immunohistochemistry staining of Ki67 and quantitative measurement of Ki67‐positive cells ratio in mouse liver at different time points after PHx. (N = 7 per group, Scale bar, 100 μm). Data are means ± SEM. *P < .05 and **P < .01