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. 2021 Jun 4;12(6):576. doi: 10.1038/s41419-021-03803-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Expression of KRIT1 in HUVECs treated with miR-21-5p mimics, miR-21-5p inhibitor, SW480/mock exosomes, SW480/miR-21-5p exosomes, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes, SW480/mock exosomes, SW480/miR-21-5p exosomes, SW480/miR-21-5p exosomes+KRIT1, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes or SW620/zip-miR-21-5p exosomes+siKRIT1 by Western blot. Expression levels were normalized to β-actin. B Effect of SW480/mock exosomes, SW480/miR-21-5p exosomes, SW480/miR-21-5p exosomes+KRIT1, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes and SW620/zip-miR-21-5p exosomes+siKRIT1 on the proliferation of HUVECs. Mean ± SEM are provided (n = 3). C Effect of SW480/mock exosomes, SW480/miR-21-5p exosomes, SW480/miR-21-5p exosomes+KRIT1, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes and SW620/zip-miR-21-5p exosomes+siKRIT1 on the migration of HUVECs by Boyden chamber. Scale bars represent 50 µm. Mean ± SEM are provided (n = 3). D Effect of SW480/mock exosomes, SW480/miR-21-5p exosomes, SW480/miR-21-5p exosomes+KRIT1, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes and SW620/zip-miR-21-5p exosomes+siKRIT1 on tube formation ability of HUVECs. Scale bars represent 50 µm. Mean ± SEM are provided (n = 3). E Effect of SW480/mock exosomes, SW480/miR-21-5p exosomes, SW480/miR-21-5p exosomes+KRIT1, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes and SW620/zip-miR-21-5p exosomes+siKRIT1 on the permeability of the HUVEC monolayers to rhodamine-dextran by in vitro permeability assay. Mean ± SEM are provided (n = 3). F The number of GFP + CRC cells invaded through the HUVEC monolayers pre-treated with SW480/mock exosomes, SW480/miR-21-5p exosomes, SW480/miR-21-5p exosomes+KRIT1, SW620/NC exosomes, SW620/zip-miR-21-5p exosomes or SW620/zip-miR-21-5p exosomes+siKRIT1. Scale bars represent 50 µm. Mean ± SEM are provided (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.