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. 2021 Jun 4;12(6):576. doi: 10.1038/s41419-021-03803-8

Fig. 6. Schematic diagram of the role of exosomal miR-21-5p secreted by CRC in angiogenesis and vascular permeability.

Fig. 6

Endothelial cells uptake exosomes secreted by CRC cells, leading to an increase of miR-21-5p expression in recipient cells. Then miR-21-5p directly suppresses KRIT1 expression in recipient endothelial cells, subsequently releases β-catenin from VE-cadherin (a protein mediates adherens junctions of endothelial cells) to nuclear, following by TCF/LEF dependent transcription, consequently induces angiogenesis and vascular permeability in CRC.