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. 2021 Jun 4;11:11840. doi: 10.1038/s41598-021-90919-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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HAVCR1 (KIM-1) expression is upregulated in RCC tumours and predicts improved overall of patient with Clear Cell and Papillary RCC. (A) Paired comparison of adjacent tissue vs matched patient tumour tissues reveals increased HAVCR1 mRNA expression in tumour tissues (****p < 0.0001; Normality and Lognormality statistical analysis). (B) Non-paired comparison of adjacent tissues vs non-matched patient tumour tissue reveals increased HAVCR1 (KIM-1) mRNA expression in tumour tissues (****p < 0.0001; Mann–Whitney t test). (C) RCC tumour stages vs adjacent tissues reveals increased HAVCR1 mRNA expression in both early and late stage RCC (****p < 0.0001; Kruskal–Wallis statistical analysis). (D) Overall patient survival vs HAVCR1 (KIM-1) mRNA expression using 50% low/high expression cut-offs reveals increased overall survival in patients with increased HAVCR1 (**p = 0.0059; Kaplan–Meier statistical analysis).