Table 1.

Gut microbiome adhesion to mucin O-glycans.

Gut microbiome	Adhesin	Mucin epitopes	Adhesin PDB entry	Reference
Commensal bacteria
Bifidobacterium bifidum	Extracellular transaldolase, extracellular sialidase	Type A antigen [Fucα1,2(GalNAcα1,3)Galβ	N/D	119
Bifidobacterium longum subsp.	Family 1 solute binding proteins (F1SBPs)	Mucin O-glycans	N/D	120
E. coli Nissle	Flagellum	Mucin O-glycans	N/D	121
Lactobacillus	Mucin-binding protein (MucBP), pili	N-acetylneuraminic acid (Neu5Ac)	4 MT5	13
Ruminococcus gnavus	Sialic acid-binding carbohydrate-binding module (CBM40) of intramolecular trans-sialidase (RgNanH)	α2,3- or α2,6-Sialyllactose	6RAB, 6RB7, 6RD1	122
Pathogens
Clostridium difficile	FliC, FliD, toxin A (TcdA)	Galα1,3Galβ1,4GlcNAc	2F6E	123
Campylobacter jejuni	Carbohydrate-lectin, FlaA, MOMP	Fucα1, 2Gal1, 4GlcNAc	N/D	124
E. coli UPEC CFT073	F9 fimbriae	Gal β1,3 N-GalNAc in core-1 and -2 O-glycans	6AS8, 6ARO, 6ARN, 6ARM, 6AOW, 6AOY, 6AOX, 5 LNG, 5 LNE	125
Enteropathogenic E. coli (EPEC) E2348/69	H6 flagella	Mucin-type core2 O-glycan	N/D	126
Uropathogenic E. coli	PapG	GalNAcβ1,3 Galα1,4Galβ1,4Glc	1J8S, 1J8R	127
Enterotoxigenic E. coli, ETEC	F17-G flagella	GlcNAcβ1,3Gal	1O9Z, 1O9 W, 1O9 V, 1ZPL	128
Shiga toxin-producing E. coli (STEC)	F18 fimbrial subunit FedF	H antigens of type 1(Fucα1,2Galβ1,3GlcNAc)	4B4P, 4B4Q, 4B4R	129
Enterohemorrhagic E. coli (EHEC)	FimH	Mannose	1KIU, 1KLF	130
Salmonella enterica serotype	Fimbrial adhesin	α(1,2)fucose	N/D	131
Listeria monocytogenes	LPXTG-internalin proteins(MucBP), LmiA	N/D	2KT7	132
Candida glabrata	Lectin-like epithelial adhesin 1 (Epa1)A	T-antigen	4D3 W	133
	Epa6A	Lactose, T-antigen, N-acetyl-D-lactosamine, lacto-N-biose, α1,3-galactobiose,Galβ1,4GlcNAc	4COU, 4COW, 4COY, 4COZ, 4COV
	Epa9A	Galβ1,4GlcNAc, lactose	4CP2, 4CP0