Fig. 6.

Two types of Notch signaling-mediated coupling between neighboring cells. In the presence of Notch-Delta signaling (top), neighboring cells form a mutual inhibitory feedback loop causing them to exhibit distinct phenotypes. One of the cells acts as the receiver (green cell in the top panel) with high Notch, low Delta expression. The other cell acts as the sender (orange cell in the top panel) with low Notch, high Delta expression. On the other hand, in the presence of Notch-Jagged signaling (bottom), neighboring cells form a mutual excitatory feedback loop causing them to acquire the same phenotype. Each cell acts both as a sender and a receiver and both cells co-express Notch receptors and Jagged ligands