Fig. 8.

Coupling between the circuits regulating EMT and stemness. The strength of coupling between the two circuits is governed by the parameters α₁ and α₂. α₁ is the maximum fold change in the rate of production of LIN28 that miR-200 can cause while α₂ is the maximum fold change in the rate of ZEB production that let-7 can cause. Since both coupling interactions are inhibitory, 0 ≤ α₁, α₂ ≤ 1 with α₁, α₂ ~ 1 indicating weak coupling