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. 2021 Jun 4;11:11836. doi: 10.1038/s41598-021-91382-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional characteristics of the different sub-clusters of IDH wild type LGG patients. (a) Overlapping the differentially expressed genes between sub-cluster1 and sub-cluster2 IDH wild type LGG patients in TCGA and CGGA datasets. (b) Un-supervised clustering heatmaps demonstrated the common differentially expressed genes between sub-cluster1 and sub-cluster2 IDH wild type LGG patients in TCGA and CGGA datasets. Red represented the up-regulated genes and blue represented the down-regulated genes. (c) Enrichment plots showed the enriched signaling pathways in different sub-clusters of IDH wild type LGG patients in TCGA and CGGA datasets. (d) Enriched transcription factors in different sub-clusters of IDH wild type LGG patients in TCGA and CGGA datasets. (e) Enrichment plots of RUNX1 transcription factor in different stromal score and immune score IDH wild type LGG patients in TCGA and CGGA datasets.