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. 2021 Jun 4;11:11836. doi: 10.1038/s41598-021-91382-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcription factor RUNX1 is up-regulated in sub-cluster1 and associated with the worse clinical outcomes of IDH wild type or IDH mutant LGG or glioma patients. (a) Box plots showed the expression levels of RUNX1 in sub-cluster1 and sub-cluster2 IDH wild type LGG patients in TCGA and CGGA datasets. P values were determined by two tails paired Student’s t test. (b) Box plots showed the RUNX1 expression levels in TCGA and CGGA IDH wild type LGG patients with higher stromal or immune score (red) or with lower stromal or immune score (blue). (c) The Kaplan–Meier Plotters showed the associations between RUNX1 expression and overall survival in IDH wild type LGG patients in TCGA and CGGA datasets. P values showed the different overall survival between RUNX1 highly expressed IDH wild type LGG patients (red) and RUNX1 lowly expressed IDH wild type LGG patients (black). (d) The Kaplan–Meier Plotters showed the associations between RUNX1 expression and overall survival in IDH mutant LGG patients in TCGA and CGGA datasets. (e) The expression levels of RUNX1 in LGG patients with (red) or without (blue) IDH mutations in TCGA and CGGA datasets. (f) The Kaplan–Meier Plotters showed the correlations of RUNX1 expression levels and LGG overall survival in TCGA and CGGA datasets. (g) Box plots demonstrated the expression levels of RUNX1 in grade II (LGG), grade III (LGG) or grade IV (GBM) glioma patients in TCGA and CGGA datasets. (h) The Kaplan–Meier Plotters showed the correlations of RUNX1 expression levels and glioma overall survival in TCGA and CGGA datasets.