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. 2021 Jun 4;11:11836. doi: 10.1038/s41598-021-91382-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prognostic significance of RUNX1 target genes. (a) The Kaplan–Meier Plotters showed the correlations of the regulatory impact of RUNX1 and overall survival of IDH wild type LGG in TCGA and CGGA datasets. (b) The Kaplan–Meier Plotters showed the correlations of the regulatory impact of RUNX1 and overall survival of LGG in TCGA and CGGA datasets. (c) Un-supervised clustering heatmaps demonstrated the expression of RUNX1 target genes in IDH wild type LGG patients in TCGA dataset. (d) Univariate cox regression analysis showed the prognostic significance of RUNX1 target genes in IDH wild type LGG patients in TCGA and CGGA datasets. HR represented hazard ratio.