TABLE 1.
‘Speech perception’: Speech intelligibility after cochlear implantation with or without local application of UC‐MSC‐EVs
| Preoperative FBM (unaided, headphones, dB optimal) | ||
|---|---|---|
| Left | Right | |
| 110 dB (15%) | 110 dB (65%) | |
| Postoperative FBM | ||
| Month | Left, EVs | Right, control |
| FF | 50% | 80% |
| 3 | 55% | 65% |
| 6 | 75% | 65% |
| 12 | 80% | 90% |
| 24 | 90% | 95% |
| Postoperative HSM 10 dB SNR | ||
| Month | Left, EVs | Right, control |
| FF | 65% | 37% |
| 3 | 85% | 69% |
| 6 | 85% | 60% |
| 12 | 89% | 81% |
| 24 | 90% | 85% |
| Postoperative HSM 5 dB SNR | ||
| Month | Left, EVs | Right, control |
| FF | 25% | n.d. |
| 3 | 41% | n.d. |
| 6 | 62% | n.d. |
| 12 | 56% | 49% |
| 24 | 64% | 38% |
| Postoperative OLSA 50% | ||
| Month | Left, EVs | Right, control |
| 12 | ‐0.7 dB SNR | ‐2.0 dB SNR |
| 24 | ‐1.6 dB SNR | n.d. |
Abbreviations: dB, decibel; EVs, Extracellular vesicles derived from umbilical cord‐mesenchymal stromal cells; FBM, Freiburger monosyllabic test; FF, first fitting; HSM, Hochmair‐Schulz‐Moser sentence test; n.d., not determined; OLSA, Oldenburg sentence test; SNR, signal to noise ratio.