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. 2021 Feb 18;29(6):2008–2018. doi: 10.1016/j.ymthe.2021.02.019

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Histological appearance and C7 expression in gene-corrected grafts

(A–F) Sections from representative grafts generated from (A and B) uncorrected RDEB (P1), (C and D) HDR-corrected RDEB (P1 HDR), and (E and F) healthy donor control (Co) cells. (A, C, and E) Hematoxylin and eosin (H&E) staining; insets show immunohistochemistry (IHC) detection of human involucrin. (B, D, and F) Anti-C7 IHC staining. The asterisks in (A) and (B) and the inset in (A) indicate the epidermal-dermal separation in uncorrected grafts. Scale bars, 100 μm.