Figure 3.

Expression of TAGLN in tumor vessels is related to TB and prognosis of human BC

(A) Tumor vessels in paracancerous tissue had increased PDGFRβ⁺ pericyte coverage, collagen type IV⁺ basement membrane coverage, distribution of VE-cadherin, and higher TAGLN coverage in endothelial vessels than in the tumor regions. CD34⁺ tumor blood vessels were stained for PDGFRβ, collagen type IV⁺, VE-cadherin, and TAGLN. PT, paracancerous tissue; T, tumor region. (B) BC tissues with high clinical stage had fewer numbers of TAGLN positively stained blood vessels. (C) The reduced number of TAGLN positively stained blood vessels was related to the large tumor size, high lymph node status, and pathological grade. (D) BC tissues with a high number of TB displayed fewer TAGLN positively stained blood vessels. (E) The reduced number of TAGLN positively stained blood vessels was related to the low survival rate in patients with BC. ∗p < 0.05, ∗∗p < 0.01.