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. 2021 Feb 10;29(6):2151–2166. doi: 10.1016/j.ymthe.2021.02.009

Figure 5.

Figure 5

TAGLN knockout in mice induces tumor progression and tumor vessel abnormalization, and SAA enhanced DPP delivery to tumors

(A) Growth of E0771 tumors and survival curves of E0771 tumor-bearing WT or Tagln−/− mice with or without SAA treatment. ∗p < 0.05 versus WT. (B) Representative images of pulmonary metastasis areas in WT or Tagln−/− mice. The dotted line demarcates the metastasis areas in the lung tissue. (C) Representative images and quantification for CD34+ vascular areas, Hypoxyprobe+ regions in tumors, dextran leakage, as well as lectin perfusion from tumor vessels. (D) Representative images for the coverage of PDGFRβ+ pericytes, coverage of type IV collagen+ basement membrane, along with the distribution of VE-cadherin and TAGLN within the CD34-labeled endothelial blood vessels. (E) The tumor growth curve and survival rate curve of the transplanted E0771 tumor with different drug treatment. (F) Representative images and quantification of the lung metastasis areas of the tumor-bearing mice. The dotted line demarcates the metastasis areas in the lung tissue. (G) Images and comparison of the necrotic areas of the transplanted tumors. Solid lines demarcate the necrosis areas. ∗p < 0.05, ∗∗p < 0.01, #p < 0.05, compared to the DDP group.