Figure 8.

Exosomal miR-22-3p enhanced tumor progression and angiogenesis of WT tumors but did not affect Tagln^−/− tumors

(A) The panel on the left shows typical images for E0771 xenografts obtained in WT or Tagln^−/− mice with different treatments, whereas that on the right presents the growth curve of xenograft volume. ∗p < 0.05. (B) The survival curve of E0771-bearing WT or Tagln^−/− mice. ∗p < 0.05 versus WT; ^#p < 0.05 versus exosomes. (C) Representative images and quantification for vascular areas, Hypoxyprobe⁺ regions in WT or Tagln^−/− tumors, lectin perfusion, and dextran leakage from tumor vessels of the transplanted tumors. (D) Coverage of PDGFRβ⁺ pericytes, coverage of type IV collagen⁺ basement membrane, and the distribution of VE-cadherin within CD34-labeled endothelial blood vessels in tumors harvested on day 24.