Table 2.
Association of Predictors for Change in eGFR Post–LVAD Implantation in Univariable and Multivariable Analysis
| Variablea | Univariable Analysis |
Multivariable Analysis |
|||
|---|---|---|---|---|---|
| 1 mo (n = 131) |
1 mo (n = 131) |
3 mo (n = 127) |
6 mo (n = 106) |
12 mo (n = 66) |
|
| β Coefficient (95% CI) | β Coefficient (95% CI) | β Coefficient (95% CI) | β Coefficient (95% CI) | β Coefficient (95% CI) | |
| Age | −4.14 (−7.79 to −0.49) | −7.14 (−11.10 to −3.17)b | −4.76 (−8.93 to −0.59)b | −3.90 (−7.86 to 0.07) | −5.60 (−9.50 to −1.69)b |
| Male sex | 7.21 (−2.63 to 17.04) | 3.33 (−5.53 to 12.19) | 6.27 (−3.21 to 15.76) | 1.49 (−7.84 to 10.81) | 8.31 (−1.55 to 18.17) |
| African American | −3.37 (−13.46 to 6.72) | −3.85 (−12.59 to 4.88) | 0.07 (−9.28 to 9.41) | −5.87 (−15.39 to 3.66) | 0.23 (−9.17 to 9.64) |
| Diabetes mellitus | −8.34 (−15.77 to −0.91) | −10.36 (−17.74 to −2.99)b | −3.57 (−11.47 to 4.34) | 1.01 (−6.62 to 8.64) | 4.42 (−4.11 to 12.96) |
| Inotropes in hospital vs not receiving inotropes | 12.97 (2.57 to 23.37) | 5.07 (−4.53 to 14.66) | 7.83 (−2.14 to 17.80) | 2.58 (−6.69 to 11.85) | 2.16 (−8.22 to 12.54) |
| Log SUN (SD = 0.23 log units) | 5.28 (1.68 to 8.89) | 2.84 (−1.50 to 7.18) | 1.13 (−3.45 to 5.71) | −1.67 (−5.98 to 2.63) | −3.05 (−8.40 to 2.30) |
| Log bilirubin (SD = 0.32 log units) | 5.84 (2.25 to 9.42) | 2.31 (−1.21 to 5.83) | −0.13 (−3.86 to 3.60) | 2.48 (−1.09 to 6.04) | 4.00 (0.18 to 7.82)b |
| Log ALT (SD = 0.29 log units) | 4.28 (0.30 to 8.27) | 3.29 (−0.15 to 6.72) | 2.27 (−1.47 to 6.01) | −0.41 (−3.71 to 2.87) | −1.71 (−5.95 to 2.54) |
| Pre-LVAD eGFR | −4.67 (−8.30 to −1.04) | −7.72 (−12.34 to −3.10)b | −8.54 (−13.43 to −3.66)b | −10.16 (−14.76 to −5.56)b | −9.71 (−14.48 to −4.93)b |
| Pre-LVAD creatinine | 5.56 (1.97 to 9.15) | ||||
Abbreviations: ALT, alanine aminotransferase; eGFR, estimated glomerular filtration rate; LVAD, left ventricular assist device; SD, standard deviation; SUN, serum urea nitrogen.
a
Continuous variables are reported per 1 SD increase.
b
Values in multivariable analysis have P < 0.05.