Figure 1.

Ultrastructural findings of the kidney biopsies. (A, B) Patient 3. (A) Podocyte with several zebra bodies (arrowed and framed box around). The maximum number of zebra bodies in a single podocyte was 6 in this patient. (B) High-magnification image of the boxed zebra body. (C, D) Patient 2. (C) Podocyte with subtle zebra bodies (arrowed and framed box around). Most zebra bodies in hydroxychloroquine-treated patients were like these and difficult to detect, though certainly recognizable in a high-magnification image. (D) High-magnification image of the boxed zebra body. (E) Podocyte from a male patient with Fabry disease shows numerous zebra bodies. (A, C, E) Presented in the same magnification, though the size and number of zebra bodies differ between (A, C) hydroxychloroquine-treated patients and (E) patient with Fabry disease.