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. 2021 May 11;10(11):3674–3688. doi: 10.1002/cam4.3911

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© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Reduced expression of USP53 in renal cell carcinoma. (A) GES database (GES66271/GES76207/GES36895/GES26574) analysis showed compared with normal tissues; the expression of USP53 in ccRCC tissues was significantly reduced. (B) TCGA‐KIRC database analysis shows the expression of USP53 in ccRCC tissues was significantly reduced. (C) Low expression of USP53 is positively correlated with tumor grade. (D) Low expression of USP53 is positively correlated with poor prognosis. (E) Western blot assays show that the expression of USP53 in tumor cell lines (786‐O, Caki‐1, SK‐NEP‐1, SW‐13) is significantly reduced compared with normal cell lines (293T). (F) Immunohistochemical staining shoe that the expression of USP53 in tumor tissues was significantly lower than paracancerous tissues. (p < 0.0001, HR = 1.816, 59% CI: 1.347‐2.448)