FIGURE 3.

Subgrouping of the training set by NMF and the association of subgroups with genetic subtypes. (A) A consensus matrix for rank 4 NMF, averaging the top 20 from 60 runs. A pixel is coloured from blue, when the pair of samples are never in the same cluster, to red, when the pair of samples are always in the same cluster. On the left of the consensus matrix, the hierarchical clustering of samples is shown. (B) Annotation tracks for consensus, subgroups, genetic subtypes, organism parts, white blood cell at diagnosis, age, race and gender. Legends and scales of the tracks are shown on the right, where “Hyperdiploidy” is short for “Hyperdiploidy without trisomy of both chromosomes 4 and 10”, and “Trisomy of 4/10” is short for “Trisomy of both chromosomes 4 and 10”