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. 2021 Jun 5;278:114303. doi: 10.1016/j.jep.2021.114303

Fig. 3.

Fig. 3

Quinoline-2-carboxylic acids were main active components in Ephedra sinica disrupting the interaction between ACE2 and RBD. (A) The structure of quinoline-2-carboxylic acids in ESE. (B) Chromatograms of compounds 1–3, the knock-out sample and the knock-in sample. (C) The inhibitory efficacy of each fractions on ACE2-RBD interaction. (D–F) The inhibitory efficacy of compounds 1–3 on ACE2-RBD interaction. Data are shown as mean ± SEM of six independent assays. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with solvent.