Table 1.
Retention time, MS data and NMR data for identification of PPI inhibitors in Ephedra sinica Stapf.
| Compound No. | Retention time (min) | [M+H] + m/z | Formula | 1H NMR (500 MHz, DMSO) | Identification |
|---|---|---|---|---|---|
| 1 | 8.4 | 206.0437 | C10H7NO4 | 7.86 (d, J = 9.0 Hz, 1H), 7.39 (d, J = 2.5 Hz, 1H), 7.24 (dd, J = 8.9, 2.5 Hz, 1H), 6.61 (s, 1H). | 4,6-dihydroxyquinoline-2-carboxylic acid |
| 188.0337 | |||||
| 160.0386 | |||||
| 132.0426 | |||||
| 2 | 13.9 | 190.0487 | C10H7NO3 | 8.09 (d, J = 7.5 Hz, 1H), 7.96 (d, J = 8.4 Hz, 1H), 7.70 (t, J = 8.2 Hz, 1H), 7.37 (t, J = 7.5 Hz, 1H), 6.65 (s, 1H). | 4-hydroxyquinoline-2-carboxylic acid |
| 172.0373 | |||||
| 144.0433 | |||||
| 116.0490 | |||||
| 3 | 24.7 | 220.0592 | C11H9NO4 | 7.92 (d, J = 9.1 Hz, 1H), 7.47 (d, J = 2.9 Hz, 1H), 7.34 (dd, J = 9.3, 2.8 Hz, 1H), 6.60 (s, 1H), 3.85 (s, 3H). | 4-hydroxy-6-methoxyquinoline-2-carboxylic acid |
| 202.0491 | |||||
| 174.0546 | |||||
| 146.0595 |