Fig. 3.

Tissue-resident ILC2 selectively express the androgen receptor and the AR-related pioneer factor Ets1. Data were obtained from Ricardo-Gonzalez et al., 2018. ILC2 from steady state mice (n = 3–6) were sorted from BM (Lin⁻CD45⁺Yarg⁺), lung, fat, gut and skin (Lin⁻CD45⁺Red5⁺ cells) were sorted and analyzed by single-cell RNA sequencing as shown [40]. (A). Histograms show read counts obtained for the indicated sex hormone receptors Nr3c1 (glucocorticoid receptor), Esr-1 (estrogen receptor α), Esr-2 (estrogen receptor β), Ar (androgen receptor), Pgr (progesterone receptor) and Nr3c2 (mineralocorticoid receptor) from BM and tissue ILC2. (B). Heatmap showing expression Z-scores of the indicated androgen receptor co-regulators in ILC2 from BM and tissue ILC2s.