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Molecular modeling images of bivalent aptamer dissociation from exosite I on thrombin by short antidote. The radiographic crystallography data of a ternary complex of thrombin with HD1 and HD22 (PDB entry 5EW2) was used as an initial structure. The poly(dT) linker was generated and connected with HD1 and HD22 using HyperChem version 7.5 (Hypercube Inc., USA). Energy minimization was performed with AMBER force field in HyperChem
