TABLE 1.

Overview of the Evidence on Associations Between CGM-Derived Parameters of Glycemic Control and Patient-Reported Outcomes

	Type of Analysis	Type of Evidence	Limitations
Interventional studies	• Randomized controlled trials on the efficacy of CGM and AID systems • Congruent improvements of CGM-derived parameters of glycemic control and PROs, indicative of an association	• Large effect sizes regarding improvement of CGM-derived parameters • Small to medium effect sizes regarding improvement of PROs	• No direct analysis of associations • Rather optimal baseline levels of PRO measures, possible lack of room for improvement
Observational studies	• Direct analysis of the association between CGM-derived parameters and PROs	• Higher TIR associated with better mood • Higher mean glucose/more TAR associated with negative affect/anger	• Rather small sample sizes • No causality
Ongoing studies	• Using EMA and CGM to analyze immediate effects of CGM-derived parameters on PROs and vice versa	• Planned: real-time effects of glucose on PROs and vice versa • Planned: intraindividual patterns	• Publications in peer-reviewed journals pending