TABLE 5.

Analysis of Adjusted CGM Variables Tested for Associations With LGA Status

Variable	LGA (n = 98)	No LGA (n = 88)	Adjusted OR (95% CI)	P
First trimester
A1C, mmol/mol	54.1 ± 1.0	50.4 ± 9.5	1.04 (1.00–1.08)	0.02*
A1C, %	7.1 ± 1.0	6.8 ± 0.9	—	—
Mean glucose, mmol/L	7.9 ± 1.3	7.7 ± 1.5	1.16 (0.19–1.49)	0.24
SD, mmol/L	3.2 ± 0.8	3.2 ± 0.9	1.09 (0.73–1.62)	0.67
Coefficient of variation, %	40.5 ± 7.2	40.6 ± 7.3	0.99 (0.95–1.04)	0.77
TIR, %†	48.2 ± 13.6	51.9 ± 14.5	0.98 (0.95–1.00)	0.07
TAR, %	44.8 ± 14.6	40.9 ± 16.3	1.02 (1.00–1.04)	0.07
TBR, %	7.0 ± 5.1	7.2 ± 5.0	0.98 (0.92–1.05)	0.60
Second trimester
A1C, mmol/mol	46.4 ± 7.4	43.7 ± 8.3	1.05 (1.01–1.10)	0.02*
A1C, %	6.4 ± 0.7	6.1 ± 0.8	—	—
Mean glucose, mmol/L	7.6 ± 1.0	7.1 ± 1.3	1.53 (1.12–2.08)	<0.001*
SD, mmol/L	2.9 ± 0.6	2.7 ± 0.7	1.65 (1.00–2.74)	<0.05*
Coefficient of variation, %	37.8 ± 5.9	37.7 ± 6.7	1.00 (0.95–1.06)	0.93
TIR, %†	51.8 ± 12.3	57.9 ± 14.4	0.96 (0.94–0.99)	<0.01*
TAR, %	41.9 ± 12.8	34.0 ± 15.9	1.04 (1.02–1.07)	<0.001*
TBR, %	6.4 ± 4.5	8.0 ± 5.7	0.93 (0.87–0.99)	0.02*
Third trimester
A1C, mmol/mol	47.2 ± 6.7	44.0 ± 8.2	1.06 (1.02–1.11)	<0.01*
A1C, %	6.5 ± 0.6	6.2 ± 0.8	—	—
Mean glucose, mmol/L	7.3 ± 1.1	6.8 ± 1.1	1.57 (1.12–2.19)	<0.001*
SD, mmol/L	2.6 ± 0.6	2.5 ± 0.6	1.60 (0.92–2.77)	0.09
Coefficient of variation, %	35.9 ± 5.5	36.1 ± 6.2	0.99 (0.94–1.05)	0.84
TIR, %†	57.6 ± 12.8	62.2 ± 13.4	0.97 (0.95–1.00)	0.04*
TAR, %	37.0 ± 13.5	30.2 ± 15.3	1.03 (1.01–1.06)	<0.01*
TBR, %	5.4 ± 4.4	7.6 ± 6.4	0.92 (0.86–0.98)	<0.01*

Adjusted for age, smoking status, BMI, and CGM device. Data in LGA and non-LGA columns are mean ± SD.

^*Statistically significant.

^†TIR 63–140 mg/dL (3.5–7.8 mmol/L). Adapted from ref. 2.