Table 6.
Literature review for usage of ADSCs in nerve regeneration studies
| Study | Subjects/animals | Method of application/Type of stem cells/Studied nerve | Results |
|---|---|---|---|
| Braga-Silva et al.(2008) | Human | Silicon tubes empty or filled with bone marrow mononuclear cells; Median and ulnar nerve reconstruction | Enhanced motor, sensation, pain and function in the group treated with silicon tubes filled with bone marrow mononuclear cells |
| Di Summa et al.(2010) | Rats | Fibrin nerve conduits seeded with various cell types/primary Schwann cells and adult stem cells; ADSCs differentiated into a Schwann cell-like phenotype/repair of sciatic nerve injury | Differentiated ADSCs enhanced regeneration in a similar manner to differentiated bone marrow mesenchymal stem cells |
| Liu et al. (2011) | Rats | Acellular nerve injected (by microinjector) with allogenic rat ADSCs/repair of sciatic nerve injury | Better outcome in acellular nerves (10 mm) implanted with ADSCs |
| Li et al. (2013) | Human | After radial nerve neurolysis, nerve was enwrapped with the prepared nerve conduit of amniotic membrane enriched with human umbilical cord mesenchymal stem cell | Enhanced motor and sensation function in the group with mesenchymal stem cells |
| Tabakow et al.(2014) | Human | Transplantation of bulbar olfactory ensheathing cells in microinjection with peripheral nerve grafts in spine reconstruction | Recovery of motor and sensation function in human after spinal cord injury |
| Abbas et al.(2016) | Rats | Microinjections with rat ADSCs/sciatic nerve used for crossfacial nerve graft for facial nerve repair | Enhanced recovery after cross-facial nerve grafting |
| Klein et al.(2016) | Rats | Collagen I type conduits pre-seeded with either Schwann cells or rat ADSCs differentiated into Schwann cells | Demonstrated promising results for the outcome of nerve regeneration in nerve defects |
| Masgutov et al.(2016) | Rats | Intra-operative injection of xenotransplanted human ADSCs into the proximal and distal stumps/post-traumatic regeneration of rat sciatic nerve | Human ADSCs promoted neuronal survival in the spinal ganglion, fuel axonal repair, and stimulate the regeneration of peripheral nerves |
| Shimizu et al.(2018) | Rats | Polyglycolic acid-collagen nerve conduits; rat ADSC and stromal vascular fraction/facial nerve | ADSCs and the stromal vascular fraction promoted nerve regeneration |
ADSC: Adipose-derived stem cells.