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. 2021 Jun 4;22:412. doi: 10.1186/s12864-020-07289-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Overview of annotated genes and unannotated transcripts enriched in BM-MSCs. a Left pannels represented: i/ Ensembl v90 transcript categories and distribution, ii/ transcripts distribution expressed in MSCs, showing unnatotated transcripts obtained with ab initio reconstruction by StringTie vs annotated transcripts (expression >0.1 TPM), iii/ predicted lncRNAs from unnanotated reconstructed transcripts include new lncRNAs with intergenic (Mlinc) and antisens (Mlncoa) RNA categories. b-c-d Distribution of transcript length, exon length and GC percentage across different categories respectively with the same colors as in a pannel: coding transcripts (blue), annotated lincRNA (pink), annotated overlapping antisens lncRNA (purple), novel lincRNA (Mlincs, yellow), novel overlapping antisens RNA (Mloanc, red). e Representation of annotated genes (top pannel) and unannotated transcripts (bottom pannel) overexpresed in MSC versus non-MSC types (log2FC >0.5 and padj <0.05), separately showed in MA plot. f Total number of transcripts by category. The colored bar indicated the number of differentially expressed annotated genes (Ensembl v90) and unannotated transcripts (Mlinc and Mloanc). gGlobal expression in BM-MSCs (with Sleuth normalisation) of the same categories as in f for annotated genes and unannotated transcripts