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. 2021 Jun 4;22:412. doi: 10.1186/s12864-020-07289-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Selection of a refined set of the best candidates by random forest (top35), long-read sequencing and epigenetic features. a Expression of the best MSC-specific candidates selected by Boruta machine learning along MSC group and not MSC cohorts. Left pannel: top35 most relevant annotated genes (non-coding included); Right pannel: unannotated intergenic lncRNAs (Mlincs) and their average importance scores determined by Boruta method displayed in upside line plot. b Genomic visualisation of Mlincs 28428 (up left panel), 64225 (up right panel), 128022 (down left panel), and 89912 (down right panel). Predictions (Mlinc orange) from short reads alignment of all MSC group files (blue/magenta and BAM visualisation), are compared with unoriented long-read alignments (grey). Additional epigenomic features are shown to reveal active transcriptional activity from trimethylation of Histone H3 (H3K4me3), acetylation of Histone H3 H3K27 in MSCs (H3K4me3 and H3K27ac, green), and Dnase sensibitity hotspots of MSC (MSC DNAse, red)